| Tissue Specificity | Expressed in all tissues tested. |
| Post Translational Modifications | Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation. |
| Function | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production. Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling. As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation. Mediates the autophagic degradation of other substrates including TICAM1. |
| Protein Name | Tax1-Binding Protein 1Traf6-Binding Protein |
| Database Links | Reactome: R-HSA-5357905Reactome: R-HSA-936440 |
| Cellular Localisation | CytoplasmMitochondrionPreautophagosomal StructureCytoplasmic VesicleAutophagosome |
| Alternative Antibody Names | Anti-Tax1-Binding Protein 1 antibodyAnti-Traf6-Binding Protein antibodyAnti-TAX1BP1 antibodyAnti-T6BP antibodyAnti-PRO0105 antibody |
Information sourced from Uniprot.org
