Anti-TAS2R43 antibody (260-309 aa) (STJ13102567)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 260-309 of human TAS2R43 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-TAS2R43 (260-309 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | TAS2R43 |
| Gene ID | 259289 |
| Uniprot ID | T2R43_HUMAN |
| Immunogen | A synthetic peptide from aa region 260-309 of human TAS2R43 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 260-309 aa |
| Specificity | Specific for TAS2R43 |
Additional Info
| Function | Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways. |
| Protein Name | Taste Receptor Type 2 Member 43T2r43Taste Receptor Type 2 Member 52T2r52 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-420499Reactome: R-HSA-9717207 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell ProjectionCilium MembraneIn Airway Epithelial CellsLocalizes To Motile Cilia |
| Alternative Antibody Names | Anti-Taste Receptor Type 2 Member 43 antibodyAnti-T2r43 antibodyAnti-Taste Receptor Type 2 Member 52 antibodyAnti-T2r52 antibodyAnti-TAS2R43 antibody |
Information sourced from Uniprot.org