| Post Translational Modifications | Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated at Ser-324 and on Tyr residues during T cell activation. Phosphorylated by LRRK2. |
| Function | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells. Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation. Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells. Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells. Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway. Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis. Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines. Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue. |
| Protein Name | Serine/Threonine-Protein Kinase Tao3Cutaneous T-Cell Lymphoma-Associated Antigen Hd-Cl-09Ctcl-Associated Antigen Hd-Cl-09Dendritic Cell-Derived Protein KinaseJnk/Sapk-Inhibitory KinaseJun Kinase-Inhibitory KinaseKinase From Chicken Homolog AHkfc-AThousand And One Amino Acid Protein 3 |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinMembrane RaftLipid DropletLocated Primarily Outside Cell Membrane Rafts And Remains Outside Upon Canonical Tcr LigationA Small Pool Is Detectable In Cell Membrane Rafts In Resting Conditions But Relocates Outside The Rafts Upon Tcr SignalingLocalizes To Lipid Droplets In Hepatocytes |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tao3 antibodyAnti-Cutaneous T-Cell Lymphoma-Associated Antigen Hd-Cl-09 antibodyAnti-Ctcl-Associated Antigen Hd-Cl-09 antibodyAnti-Dendritic Cell-Derived Protein Kinase antibodyAnti-Jnk/Sapk-Inhibitory Kinase antibodyAnti-Jun Kinase-Inhibitory Kinase antibodyAnti-Kinase From Chicken Homolog A antibodyAnti-Hkfc-A antibodyAnti-Thousand And One Amino Acid Protein 3 antibodyAnti-TAOK3 antibodyAnti-DPK antibodyAnti-JIK antibodyAnti-KDS antibodyAnti-MAP3K18 antibody |
Information sourced from Uniprot.org
