• Western blot analysis of lysates from NIH/3T3 cells, using TAOK1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TAOK1 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-TAOK1 antibody (431-480 aa) (STJ95247)

SKU:
STJ95247

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Serine/threonine-protein kinase TAO1 (431-480 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TAOK1
Gene ID: 57551
Uniprot ID: TAOK1_HUMAN
Immunogen Region: 431-480 aa
Specificity: PSK2 Polyclonal Antibody detects endogenous levels of PSK2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TAOK1 at the amino acid range 431-480
Post Translational Modifications Proteolytically processed by caspase-3 (CASP3). Autophosphorylated. Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2.
Function Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system. Also plays a role in the regulation of neuronal migration to the cortical plate.
Protein Name Serine/Threonine-Protein Kinase Tao1
Kinase From Chicken Homolog B
Hkfc-B
Mark Kinase
Markk
Prostate-Derived Sterile 20-Like Kinase 2
Psk-2
Psk2
Prostate-Derived Ste20-Like Kinase 2
Thousand And One Amino Acid Protein Kinase 1
Taok1
Htaok1
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-5663220
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Tao1 antibody
Anti-Kinase From Chicken Homolog B antibody
Anti-Hkfc-B antibody
Anti-Mark Kinase antibody
Anti-Markk antibody
Anti-Prostate-Derived Sterile 20-Like Kinase 2 antibody
Anti-Psk-2 antibody
Anti-Psk2 antibody
Anti-Prostate-Derived Ste20-Like Kinase 2 antibody
Anti-Thousand And One Amino Acid Protein Kinase 1 antibody
Anti-Taok1 antibody
Anti-Htaok1 antibody
Anti-TAOK1 antibody
Anti-KIAA1361 antibody
Anti-MAP3K16 antibody
Anti-MARKK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance