Anti-TALIN-1 antibody [97H6] (STJ16101946)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
Immunogenhis-tagged polypeptide containing residues 489–911 of mouse talin1
General Information
| Short Description | Mouse monoclonal anti-TALIN-1 for use in IF, IP, IHC-P and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IP/IHC-P/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 97H6 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Formulation | PBS with <0.1% sodium azide |
| Storage Instruction | Store aliquots at-20°C, and thawed aliquots at 2-8°C. |
Target Information
| Gene Symbol | TLN1 |
| Gene ID | 7094 |
| Uniprot ID | TLN1_HUMAN |
| Immunogen | his-tagged polypeptide containing residues 489–911 of mouse talin1 |
Additional Info
| Tissue Specificity | Isoform 2: Expressed at low to non-detectable levels in many tissues but highly expressed in skin and pancreas with other tissues including kidney cortex, endocervix, testis, pituitary, liver, and spleen also showing robust expression. |
| Function | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. |
| Protein Name | Talin-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-381038Reactome: R-HSA-399955Reactome: R-HSA-445355Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell SurfaceCell JunctionFocal AdhesionColocalizes With Layn At The Membrane RufflesLocalized Preferentially In Focal Adhesions Than Fibrillar Adhesions |
| Alternative Antibody Names | Anti-Talin-1 antibodyAnti-TLN1 antibodyAnti-KIAA1027 antibodyAnti-TLN antibody |
Information sourced from Uniprot.org