Anti-TAL1 antibody (242-331) (STJ114793)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TAL1 (242-331) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TAL1 |
| Gene ID | 6886 |
| Uniprot ID | TAL1_HUMAN |
| Immunogen Region | 242-331 |
| Immunogen Sequence | LLNDQEEEGTQRAKTGKDPV VGAGGGGGGGGGGAPPDDLL QDVLSPNSSCGSSLDGAASP DSYTEEPAPKHTARSLHPAM LPAADGAGPR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 242-331 of human TAL1 (NP_003180.1). |
Additional Info
| Tissue Specificity | Leukemic stem cell. |
| Post Translational Modifications | Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia. Ubiquitinated.subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells. |
| Function | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. |
| Protein Name | T-Cell Acute Lymphocytic Leukemia Protein 1Tal-1Class A Basic Helix-Loop-Helix Protein 17Bhlha17Stem Cell ProteinT-Cell Leukemia/Lymphoma Protein 5 |
| Database Links | Reactome: R-HSA-8939236Reactome: R-HSA-9616222 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-T-Cell Acute Lymphocytic Leukemia Protein 1 antibodyAnti-Tal-1 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 17 antibodyAnti-Bhlha17 antibodyAnti-Stem Cell Protein antibodyAnti-T-Cell Leukemia/Lymphoma Protein 5 antibodyAnti-TAL1 antibodyAnti-BHLHA17 antibodyAnti-SCL antibodyAnti-TCL5 antibody |
Information sourced from Uniprot.org