| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TAF6 (350-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TAF6 |
| Gene ID: |
6878 |
| Uniprot ID: |
TAF6_HUMAN |
| Immunogen Region: |
350-450 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TAF6 (XP_006716164.1). |
| Immunogen Sequence: |
TKSWVDEKTPWTTRYGSIAG LAELGHDVIKTLILPRLQQE GERIRSVLDGPVLSNIDRIG ADHVQSLLLKHCAPVLAKLR PPPDNQDAYRAEFGSLGPLL C |
| Post Translational Modifications | Isoform 4: In cells undergoing apoptosis, cleaved in a caspase-dependent manner to produce a 40 kDa product. |
| Function | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF6 homodimer connects TFIID modules, forming a rigid core. Isoform 4: Transcriptional regulator which acts primarily as a positive regulator of transcription. Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis. Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1. In contrast, down-regulates transcription of MDM2. Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1. Can also activate transcription and apoptosis independently of TP53. Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA. |
| Protein Name | Transcription Initiation Factor Tfiid Subunit 6Rna Polymerase Ii Tbp-Associated Factor Subunit ETranscription Initiation Factor Tfiid 70 Kda SubunitTaf(Ii70Tafii-70Tafii70Transcription Initiation Factor Tfiid 80 Kda SubunitTaf(Ii80Tafii-80Tafii80 |
| Database Links | Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-674695Reactome: R-HSA-6804756Reactome: R-HSA-6807505Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-75953Reactome: R-HSA-76042 |
| Cellular Localisation | NucleusIsoform 4: Nucleus |
| Alternative Antibody Names | Anti-Transcription Initiation Factor Tfiid Subunit 6 antibodyAnti-Rna Polymerase Ii Tbp-Associated Factor Subunit E antibodyAnti-Transcription Initiation Factor Tfiid 70 Kda Subunit antibodyAnti-Taf(Ii70 antibodyAnti-Tafii-70 antibodyAnti-Tafii70 antibodyAnti-Transcription Initiation Factor Tfiid 80 Kda Subunit antibodyAnti-Taf(Ii80 antibodyAnti-Tafii-80 antibodyAnti-Tafii80 antibodyAnti-TAF6 antibodyAnti-TAF2E antibodyAnti-TAFII70 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
