| Short Description : | Rabbit polyclonal anti-Transcriptional adapter 2-alpha (206-255 aa) for use in WB and ELISA in Human, Mouse, Rat and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000ELISA 1:10000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TADA2A |
| Gene ID: | 6871 |
| Uniprot ID: | TAD2A_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ADA2L at the amino acid range 206-255 |
| Immunogen Region: | 206-255 aa |
| Specificity: | TADA2L Polyclonal Antibody detects endogenous levels of TADA2L protein. |
| Function | Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. |
| Protein Name | Transcriptional Adapter 2-AlphaTranscriptional Adapter 2-LikeAda2-Like Protein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Transcriptional Adapter 2-Alpha antibodyAnti-Transcriptional Adapter 2-Like antibodyAnti-Ada2-Like Protein antibodyAnti-TADA2A antibodyAnti-TADA2L antibodyAnti-KL04P antibody |
Information sourced from Uniprot.org
