| Function | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell growth and differentiation. May contribute to cancer. |
| Protein Name | Transforming Acidic Coiled-Coil-Containing Protein 3Eric-1 |
| Database Links | Reactome: R-HSA-9013507Reactome: R-HSA-9604323 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleSpindle PoleIn Complex With Ckap5 Localized To Microtubule Plus-Ends In Mitosis And InterphaseIn Complex With Ckap5 And Clathrin Localized To Inter-Microtubule Bridges In Mitotic Spindles |
| Alternative Antibody Names | Anti-Transforming Acidic Coiled-Coil-Containing Protein 3 antibodyAnti-Eric-1 antibodyAnti-TACC3 antibodyAnti-ERIC1 antibody |
Information sourced from Uniprot.org
