| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TAB3 |
| Gene ID: | 257397 |
| Uniprot ID: | TAB3_HUMAN |
| Immunogen Region: | 390-480 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 390-480 of human TAB3 (NP_690000.3). |
| Immunogen Sequence: | QPSPRNQHSLYTATTPPSSS PSRGISSQPKPPFSVNPVYI TYTQPTGPSCTPSPSPRVIP NPTTVFKITVGRATTENLLN LVDQEERSAAP |
| Tissue Specificity | Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1: Major transcript. Isoform 2: Minor transcript. |
| Post Translational Modifications | Ubiquitinated.following IL1 stimulation or TRAF6 overexpression. Ubiquitinated by AMFR via 'Lys-27'-linked polyubiquitination.leading to TAK1/MAP3K7 activation. Degraded in a lysosome-dependent manner following interaction with TRIM38. Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. (Microbial infection) Methylated at Cys-692 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts zinc-binding and ability to bind 'Lys-63'-linked ubiquitin, leading to NF-kappa-B inactivation. |
| Function | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Isoform 2: May be an oncogenic factor. |
| Protein Name | Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 3Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3Nf-Kappa-B-Activating Protein 1Tak1-Binding Protein 3Tab-3Tgf-Beta-Activated Kinase 1-Binding Protein 3 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-2871837Reactome: R-HSA-445989Reactome: R-HSA-450302Reactome: R-HSA-450321Reactome: R-HSA-5357956Reactome: R-HSA-5607764Reactome: R-HSA-9014325Reactome: R-HSA-9020702Reactome: R-HSA-937042Reactome: R-HSA-937072Reactome: R-HSA-9645460Reactome: R-HSA-9705671Reactome: R-HSA-975163 |
| Alternative Antibody Names | Anti-Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 3 antibodyAnti-Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3 antibodyAnti-Nf-Kappa-B-Activating Protein 1 antibodyAnti-Tak1-Binding Protein 3 antibodyAnti-Tab-3 antibodyAnti-Tgf-Beta-Activated Kinase 1-Binding Protein 3 antibodyAnti-TAB3 antibodyAnti-MAP3K7IP3 antibody |
Information sourced from Uniprot.org
