Anti-TAB3 antibody (STJ191724)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TAB3 |
| Gene ID | 257397 |
| Uniprot ID | TAB3_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | TAB3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated.following IL1 stimulation or TRAF6 overexpression. Ubiquitinated by AMFR via 'Lys-27'-linked polyubiquitination.leading to TAK1/MAP3K7 activation. Degraded in a lysosome-dependent manner following interaction with TRIM38. Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. (Microbial infection) Methylated at Cys-692 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts zinc-binding and ability to bind 'Lys-63'-linked ubiquitin, leading to NF-kappa-B inactivation. |
| Function | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Isoform 2: May be an oncogenic factor. |
| Protein Name | Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 3Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3Nf-Kappa-B-Activating Protein 1Tak1-Binding Protein 3Tab-3Tgf-Beta-Activated Kinase 1-Binding Protein 3 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-2871837Reactome: R-HSA-445989Reactome: R-HSA-450302Reactome: R-HSA-450321Reactome: R-HSA-5357956Reactome: R-HSA-5607764Reactome: R-HSA-9014325Reactome: R-HSA-9020702Reactome: R-HSA-937042Reactome: R-HSA-937072Reactome: R-HSA-9645460Reactome: R-HSA-9705671Reactome: R-HSA-975163 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 3 antibodyAnti-Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3 antibodyAnti-Nf-Kappa-B-Activating Protein 1 antibodyAnti-Tak1-Binding Protein 3 antibodyAnti-Tab-3 antibodyAnti-Tgf-Beta-Activated Kinase 1-Binding Protein 3 antibodyAnti-TAB3 antibodyAnti-MAP3K7IP3 antibody |
Information sourced from Uniprot.org