Anti-T-bet antibody [MRQ-46] (STJ16100444)

Anti-T-bet antibody [MRQ-46] (STJ16100444)

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STJ16100444
£1,030.50 - £1,692.50
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-T-bet is suitable for use in Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : MRQ-46
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Dilution Range: IHC 1:100 – 1:500
Storage Instruction: Store at 2-8°C upon receipt.
Background T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th) 1 Tcell development from na i ve T-helper precursor cells (Thp) and redirects Th2 T-cells to Th1 development. Anti-T-bet is a marker of mature T-cells and is expressed at very low levels in Thp cells and is absent in precursor T-lymphoblastic leukemia/lymphoma cells. Scattered small lymphocytes in the interfollicular T-cell zone of reactive lymphoid tissue, including tonsil, lymph node, and spleen exhibited nuclear staining for anti-T-bet, with no anti-T-bet staining observed in germinal centers or mantle or marginal zones. T-bet is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma) , and B-cell neoplasms derived from mature B-cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia.

Information sourced from Uniprot.org

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