![Anti-T-bet antibody [MRQ-46] (STJ16100444)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149161/346783/STJ16100444_1__12290.1681998885.jpg?c=1 "Anti-T-bet antibody [MRQ-46] (STJ16100444)")
![Anti-T-bet antibody [MRQ-46] (STJ16100444)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149161/346784/STJ16100444_2__49868.1681998885.jpg?c=1 "Anti-T-bet antibody [MRQ-46] (STJ16100444)")
![Anti-T-bet antibody [MRQ-46] (STJ16100444)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149161/346785/STJ16100444_3__65857.1681998886.jpg?c=1 "Anti-T-bet antibody [MRQ-46] (STJ16100444)")
![Anti-T-bet antibody [MRQ-46] (STJ16100444)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149161/346783/STJ16100444_1__12290.1681998885.jpg?c=1 "Anti-T-bet antibody [MRQ-46] (STJ16100444)")
| Short Description : | Rabbit monoclonal anti-T-bet for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | MRQ-46 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Dilution Range: | IHC 1:100 – 1:500 |
| Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction: | Store at 2-8°C for up to 1-year, upon receipt. |
| Background | T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th) 1 Tcell development from i ve T-helper precursor cells (Thp) and redirects Th2 T-cells to Th1 development. Anti-T-bet is a marker of mature T-cells and is expressed at very low levels in Thp cells and is absent in precursor T-lymphoblastic leukemia/lymphoma cells. Scattered small lymphocytes in the interfollicular T-cell zone of reactive lymphoid tissue, including tonsil, lymph node, and spleen exhibited nuclear staining for anti-T-bet, with no anti-T-bet staining observed in germinal centers or mantle or marginal zones. T-bet is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma) , and B-cell neoplasms derived from mature B-cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia. |
Information sourced from Uniprot.org
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