Anti-SYVN1 antibody (STJA0006769)

SKU:
STJA0006769

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase synoviolin is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SYVN1
Gene ID: 84447
Uniprot ID: SYVN1_HUMAN
Specificity: This antibody detects endogenous levels of HRD1/SYVN1 at Human, Mouse
Immunogen: Synthesized peptide derived from human HRD1/SYVN1
Post Translational Modifications Not N-glycosylated. Auto-ubiquitinated.
Function E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1. During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells.
Protein Name E3 Ubiquitin-Protein Ligase Synoviolin
Ring-Type E3 Ubiquitin Transferase Synoviolin
Synovial Apoptosis Inhibitor 1
Database Links Reactome: R-HSA-381038
Reactome: R-HSA-5358346
Reactome: R-HSA-5362768
Reactome: R-HSA-901032
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Synoviolin antibody
Anti-Ring-Type E3 Ubiquitin Transferase Synoviolin antibody
Anti-Synovial Apoptosis Inhibitor 1 antibody
Anti-SYVN1 antibody
Anti-HRD1 antibody
Anti-KIAA1810 antibody

Information sourced from Uniprot.org

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