| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SYT12 |
| Gene ID: | 91683 |
| Uniprot ID: | SYT12_HUMAN |
| Immunogen Region: | 95-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 95-200 of human SYT12 (NP_001171351.1). |
| Immunogen Sequence: | KGSLSIEDTFESISELGPLE LMGRELDLAPYGTLRKSQSA DSLNSISSVSNTFGQDFTLG QVEVSMEYDTASHTLNVAVM QGKDLLEREEASFESCFMRV SLLPDE |
| Post Translational Modifications | Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation. |
| Function | Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus. |
| Protein Name | Synaptotagmin-12Synaptotagmin XiiSytxii |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Synaptotagmin-12 antibodyAnti-Synaptotagmin Xii antibodyAnti-Sytxii antibodyAnti-SYT12 antibody |
Information sourced from Uniprot.org