| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat/Bovine/Chicken/Human/Non-Human Primates |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-synaptotagmin 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: |
This antibody was antigen affinity purified from pooled serum. |
| Dilution Range: |
WB 1:1000IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Syt1 |
| Gene ID: |
25716 |
| Uniprot ID: |
SYT1_RAT |
| Immunogen: |
Synthetic peptide corresponding to amino acid residues specific to synaptotagmin 1 conjugated to KLH. |
| Tissue Specificity | Expressed in the brain (at protein level). Predominantly expressed in rostral, phylogenetically younger brain regions, and in some endocrine tissues. |
| Post Translational Modifications | Glycosylated. |
| Function | Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner.these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes. (Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB).interaction is improved in the presence of gangliosides. BoNT/B toxin binds to the membrane proximal vesicular domain of Syt1 (residues 32-51). (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG).unlike the case with BoNT/B, interaction is not improved in the presence of gangliosides. BoNT/G toxin binds to the vesicular domain of Syt1 (residues 32-53). |
| Protein Name | Synaptotagmin-1Synaptotagmin ISytiP65 |
| Database Links | Reactome: R-RNO-181429Reactome: -RNO-181430Reactome: -RNO-210500Reactome: -RNO-212676Reactome: -RNO-264642Reactome: -RNO-8856825Reactome: -RNO-8856828Reactome: -RNO-888590 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneSingle-Pass Membrane ProteinSecretory VesicleSynaptic Vesicle MembraneChromaffin Granule MembraneCytoplasm |
| Alternative Antibody Names | Anti-Synaptotagmin-1 antibodyAnti-Synaptotagmin I antibodyAnti-Syti antibodyAnti-P65 antibodyAnti-Syt1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
