| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SYT1 |
| Gene ID: | 6857 |
| Uniprot ID: | SYT1_HUMAN |
| Immunogen Region: | 84-157 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 84-157 of human SYT1 (NP_005630.1). |
| Immunogen Sequence: | LFKKKNKKKGKEKGGKNAIN MKDVKDLGKTMKDQALKDDD AETGLTDGEEKEEPKEEEKL GKLQYSLDYDFQNN |
| Tissue Specificity | Expressed in melanocytes. |
| Post Translational Modifications | Glycosylated. |
| Function | Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner.these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes. |
| Protein Name | Synaptotagmin-1 Synaptotagmin I Syti P65 |
| Database Links | Reactome: R-HSA-181429 Reactome: R-HSA-181430 Reactome: R-HSA-210500 Reactome: R-HSA-212676 Reactome: R-HSA-264642 Reactome: R-HSA-5250958 Reactome: R-HSA-5250989 Reactome: R-HSA-6794361 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-888590 |
| Cellular Localisation | Cytoplasmic Vesicle Secretory Vesicle Membrane Single-Pass Membrane Protein Secretory Vesicle Synaptic Vesicle Membrane Chromaffin Granule Membrane Cytoplasm |
| Alternative Antibody Names | Anti-Synaptotagmin-1 antibody Anti-Synaptotagmin I antibody Anti-Syti antibody Anti-P65 antibody Anti-SYT1 antibody Anti-SVP65 antibody Anti-SYT antibody |
Information sourced from Uniprot.org