Anti-Syntrophin alpha 1 antibody [R03-4E7] (STJA0034906)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Syntrophin alpha 1
General Information
| Short Description | Rabbit monoclonal anti-Syntrophin alpha 1 for use in WB, IHC-F, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-4E7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SNTA1 |
| Gene ID | 6640 |
| Uniprot ID | SNTA1_HUMAN |
| Immunogen | A synthetic peptide of human Syntrophin alpha 1 |
Additional Info
| Tissue Specificity | High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta. |
| Post Translational Modifications | Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD. |
| Function | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate. |
| Protein Name | Alpha-1-Syntrophin59 Kda Dystrophin-Associated Protein A1 Acidic Component 1Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 1Tacip1Syntrophin-1 |
| Database Links | Reactome: R-HSA-9913351 |
| Cellular Localisation | Cell MembraneSarcolemmaPeripheral Membrane ProteinCytoplasmic SideCell JunctionCytoplasmCytoskeletonIn Skeletal MuscleIt Localizes At The Cytoplasmic Side Of The Sarcolemmal Membrane And At Neuromuscular Junctions |
| Alternative Antibody Names | Anti-Alpha-1-Syntrophin antibodyAnti-59 Kda Dystrophin-Associated Protein A1 Acidic Component 1 antibodyAnti-Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 1 antibodyAnti-Tacip1 antibodyAnti-Syntrophin-1 antibodyAnti-SNTA1 antibodyAnti-SNT1 antibody |
Information sourced from Uniprot.org