| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-SynGAP (1330-1343 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
R03-4F4 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: |
Affinity Purified |
| Concentration: |
0.3 mg/ml |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: |
SYNGAP1 |
| Gene ID: |
8831 |
| Uniprot ID: |
SYGP1_HUMAN |
| Immunogen Region: |
1330-1343 aa |
| Immunogen: |
A synthetic peptide of human SynGAP |
| Post Translational Modifications | Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity. |
| Function | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. |
| Protein Name | Ras/Rap Gtpase-Activating Protein SyngapNeuronal RasgapSynaptic Ras Gtpase-Activating Protein 1Synaptic Ras-Gap 1 |
| Database Links | Reactome: R-HSA-5658442 |
| Alternative Antibody Names | Anti-Ras/Rap Gtpase-Activating Protein Syngap antibodyAnti-Neuronal Rasgap antibodyAnti-Synaptic Ras Gtpase-Activating Protein 1 antibodyAnti-Synaptic Ras-Gap 1 antibodyAnti-SYNGAP1 antibodyAnti-KIAA1938 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
