| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse/Marmoset |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Synaptotagmin2 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Syt2 |
| Gene ID: |
20980 |
| Uniprot ID: |
SYT2_MOUSE |
| Specificity: |
Specific for SYTII. |
| Immunogen: |
A synthetic peptide from rat Synaptotagmin2 conjugated to blue carrier protein was used as the antigen. |
| Function | Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes. (Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB).interaction is improved in the presence of gangliosides. The toxin binds via the vesicular domain (residues 47-60). (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG).gangliosides are not required for (or only very slightly improve) binding to a membrane-anchored receptor fragment. The toxin binds via the vesicular domain (residues 47-55). |
| Protein Name | Synaptotagmin-2Inositol Polyphosphate-Binding ProteinIp4-Binding ProteinIp4bpSynaptotagmin IiSytii |
| Database Links | Reactome: R-MMU-8856825Reactome: -MMU-8856828 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Membrane ProteinChromaffin Granule MembraneCytoplasm |
| Alternative Antibody Names | Anti-Synaptotagmin-2 antibodyAnti-Inositol Polyphosphate-Binding Protein antibodyAnti-Ip4-Binding Protein antibodyAnti-Ip4bp antibodyAnti-Synaptotagmin Ii antibodyAnti-Sytii antibodyAnti-Syt2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
