| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Synaptotagmin-2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 50kDa band observed in Mouse Lung lysates (calculated MW of 47.2kDa according to Mouse NP_033333.2). Recommended concentration: 0.1-0.3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SYT2 |
| Gene ID: | 127833 |
| Uniprot ID: | SYT2_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_796376.2 |
| Specificity: | Reported variants represent identical protein: NP_001129976.1, NP_796376.2 |
| Immunogen Sequence: | KPEEEVDALLGKNK |
| Post Translational Modifications | Phosphorylation at Thr-199 by WNK1, changes the calcium requirement for SYT2-binding to phospholipid membranes. |
| Function | Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes. |
| Protein Name | Synaptotagmin-2Synaptotagmin IiSytii |
| Database Links | Reactome: R-HSA-5250958Reactome: R-HSA-6794361Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Membrane ProteinChromaffin Granule MembraneCytoplasm |
| Alternative Antibody Names | Anti-Synaptotagmin-2 antibodyAnti-Synaptotagmin Ii antibodyAnti-Sytii antibodyAnti-SYT2 antibody |
Information sourced from Uniprot.org
