| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Synapsin 1 (595-645 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:2000 to 1:4000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | SYN1 |
| Gene ID: | 6853 |
| Uniprot ID: | SYN1_HUMAN |
| Immunogen Region: | 595-645 aa |
| Specificity: | Specific for Synapsin-1. |
| Immunogen: | A synthetic peptide from aa region 595-645of human Synapsin 1 conjugated to blue carrier protein was used as the antigen. |
| Function | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. |
| Protein Name | Synapsin-1Brain Protein 4.1Synapsin I |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-212676Reactome: R-HSA-9662360 |
| Cellular Localisation | SynapseGolgi ApparatusPresynapseCytoplasmic VesicleSecretory VesicleSynaptic VesicleDissociates From Synaptic Vesicles And Redistributes Into The Axon During Action Potential FiringIn A Step That Precedes Fusion Of Vesicles With The Plasma MembraneReclusters To Presynapses After The Cessation Of Synaptic Activity |
| Alternative Antibody Names | Anti-Synapsin-1 antibodyAnti-Brain Protein 4.1 antibodyAnti-Synapsin I antibodyAnti-SYN1 antibody |
Information sourced from Uniprot.org