| Short Description : | Rabbit polyclonal SYCP3 (1-236) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SYCP3 |
| Gene ID: | 50511 |
| Uniprot ID: | SYCP3_HUMAN |
| Immunogen Region: | 1-236 |
| Immunogen Sequence: | MVSSGKKYSRKSGKPSVEDQ FTRAYDFETEDKKDLSGSEE DVIEGKTAVIEKRRKKRSSA GVVEDMGGEVQNMLEGVGVD INKALLAKRKRLEMYTKASL KTSNQKIEHVWKTQQDQRQK LNQEYSQQFLTLFQQWDLDM QKAEEQEEKILNMFRQQQKI LQQSRIVQSQRLKTIKQLYE QFIKSMEELEKNHDNLLTGA QNEFKKEMAMLQKKIMMETQ QQEIASVRKSLQSMLF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-236 of human SYCP3 (NP_710161.1). |
| Tissue Specificity | Testis-specific. |
| Post Translational Modifications | Phosphorylated. |
| Function | Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2. |
| Protein Name | Synaptonemal Complex Protein 3Scp-3 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | NucleusChromosomeCentromereIt Is Present In Early Unpaired CoresIn The Lateral Domains Of The Synaptonemal Complex And In The Chromosome Cores When They Separate At DiploteneIt Is Found Axial To The Metaphase I Chromosomes And In Association With Pairs Of Sister CentromeresThe Centromere-Associated Protein Becomes Dissociated From The Centromeres At Anaphase Ii And Is Not Found In Mitotic Metaphase Centromeres |
| Alternative Antibody Names | Anti-Synaptonemal Complex Protein 3 antibodyAnti-Scp-3 antibodyAnti-SYCP3 antibodyAnti-SCP3 antibody |
Information sourced from Uniprot.org
