| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SV2B (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | SV2B |
| Gene ID: | 9899 |
| Uniprot ID: | SV2B_HUMAN |
| Immunogen Region: | N-Term |
| Specificity: | Specific for SV2B. |
| Immunogen: | A synthetic peptide from n-terminal region of human Synaptic vesicle glycoprotein 2B (SV2B) conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Probably plays a role in the control of regulated secretion in neural and endocrine cells. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA).glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. |
| Protein Name | Synaptic Vesicle Glycoprotein 2b |
| Database Links | Reactome: R-HSA-5250955Reactome: R-HSA-5250968Reactome: R-HSA-5250981Reactome: R-HSA-5250992 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinAcrosomeAssociated With Synaptic-Like Microvesicles But Not With Insulin-Containing Vesicles In Insulin-Secreting Cells Of The PancreasLocalizes To Microvesicles In The PinealocytesLocalizes To The Acrosome In Spermatids |
| Alternative Antibody Names | Anti-Synaptic Vesicle Glycoprotein 2b antibodyAnti-SV2B antibodyAnti-KIAA0735 antibody |
Information sourced from Uniprot.org
