| Host: | Mouse |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Polycomb protein SUZ12 is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 2C11 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SUZ12 |
| Gene ID: | 23512 |
| Uniprot ID: | SUZ12_HUMAN |
| Specificity: | SUZ12 Monoclonal Antibody detects endogenous levels of SUZ12 protein. |
| Immunogen: | Purified recombinant fragment of human SUZ12 expressed in E. Coli. |
| Post Translational Modifications | Sumoylated, probably by PIAS2. |
| Function | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
| Protein Name | Polycomb Protein Suz12Chromatin Precipitated E2f Target 9 ProteinChet 9 ProteinJoined To Jazf1 ProteinSuppressor Of Zeste 12 Protein Homolog |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214841Reactome: R-HSA-4551638Reactome: R-HSA-5617472Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9710421 |
| Cellular Localisation | NucleusLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Antibody Names | Anti-Polycomb Protein Suz12 antibodyAnti-Chromatin Precipitated E2f Target 9 Protein antibodyAnti-Chet 9 Protein antibodyAnti-Joined To Jazf1 Protein antibodyAnti-Suppressor Of Zeste 12 Protein Homolog antibodyAnti-SUZ12 antibodyAnti-CHET9 antibodyAnti-JJAZ1 antibodyAnti-KIAA0160 antibody |
Information sourced from Uniprot.org
