Anti-SURF4 antibody (144-157 aa) [R07-1F1] (STJA0012159)

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STJA0012159-100
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Host: Rabbit
Applications: WB/ICC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Surfeit Locus Protein 4 (144-157 aa) is suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence research applications.
Clonality : Monoclonal
Clone ID : R07-1F1
Conjugation: Unconjugated
Isotype: IgG
Formulation: 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification: Affinity Purified
Concentration: 0.3 mg/ml
Dilution Range: WB 1:500-1:1000
IF 1:50-1:200
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: SURF4
Gene ID: 6836
Uniprot ID: SURF4_HUMAN
Immunogen Region: 144-157 aa
Immunogen: A synthetic peptide of human SURF4
Function Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins. Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.
Protein Name Surfeit Locus Protein 4
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-6811434
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Golgi Apparatus Membrane
Active At Endoplasmic Reticulum Exit Sites (Eres) Where It Is Incorporated Together With Its Lipoprotein Cargos Into Copii-Coated Vesicles
From The Golgi It Is Recycled Back To The Endoplasmic Reticulum
Alternative Antibody Names Anti-Surfeit Locus Protein 4 antibody
Anti-SURF4 antibody
Anti-SURF-4 antibody

Information sourced from Uniprot.org