Anti-SULT2B1 antibody (1-365) (STJ110047)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SULT2B1 (1-365) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SULT2B1 |
| Gene ID | 6820 |
| Uniprot ID | ST2B1_HUMAN |
| Immunogen Region | 1-365 |
| Immunogen Sequence | MDGPAEPQIPGLWDTYEDDI SEISQKLPGEYFRYKGVPFP VGLYSLESISLAENTQDVRD DDIFIITYPKSGTTWMIEII CLILKEGDPSWIRSVPIWER APWCETIVGAFSLPDQYSPR LMSSHLPIQIFTKAFFSSKA KVIYMGRNPRDVVVSLYHYS KIAGQLKDPGTPDQFLRDFL KGEVQFGSWFDHIKGWLRMK GKDNFLFITYEELQQDLQGS VERICGFLGRPLGKEALGS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human SULT2B1 (NP_814444.1). |
Additional Info
| Tissue Specificity | Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. |
| Post Translational Modifications | Phosphorylated. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation. Isoform 2: Sulfonates pregnenolone but not cholesterol. |
| Protein Name | Sulfotransferase 2b1Alcohol SulfotransferaseHydroxysteroid Sulfotransferase 2Sulfotransferase Family 2b Member 1Sulfotransferase Family Cytosolic 2b Member 1St2b1 |
| Database Links | Reactome: R-HSA-156584 |
| Cellular Localisation | CytoplasmCytosolMicrosomeNucleusPhosphorylation Of Ser-348 Is Required For Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Sulfotransferase 2b1 antibodyAnti-Alcohol Sulfotransferase antibodyAnti-Hydroxysteroid Sulfotransferase 2 antibodyAnti-Sulfotransferase Family 2b Member 1 antibodyAnti-Sulfotransferase Family Cytosolic 2b Member 1 antibodyAnti-St2b1 antibodyAnti-SULT2B1 antibodyAnti-HSST2 antibody |
Information sourced from Uniprot.org