| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SULT1E1 (140-294) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SULT1E1 |
| Gene ID: |
6783 |
| Uniprot ID: |
ST1E1_HUMAN |
| Immunogen Region: |
140-294 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 140-294 of human SULT1E1 (NP_005411.1). |
| Immunogen Sequence: |
YFFLMVAGHPNPGSFPEFVE KFMQGQVPYGSWYKHVKSWW EKGKSPRVLFLFYEDLKEDI RKEVIKLIHFLERKPSEELV DRIIHHTSFQEMKNNPSTNY TTLPDEIMNQKLSPFMRKGI TGDWKNHFTVALNEKFDKHY EQQMKESTLKFRTEI |
| Tissue Specificity | Liver, intestine and at lower level in the kidney. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. |
| Protein Name | Sulfotransferase 1e1St1e1Est-1Estrogen SulfotransferaseSulfotransferase - Estrogen-Preferring |
| Database Links | Reactome: R-HSA-156584Reactome: R-HSA-9753281 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Sulfotransferase 1e1 antibodyAnti-St1e1 antibodyAnti-Est-1 antibodyAnti-Estrogen Sulfotransferase antibodyAnti-Sulfotransferase - Estrogen-Preferring antibodyAnti-SULT1E1 antibodyAnti-STE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
