Anti-SULT1A1 antibody (STJA0007050)

SKU:
STJA0007050

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sulfotransferase 1A1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SULT1A1
Gene ID: 6817
Uniprot ID: ST1A1_HUMAN
Specificity: This antibody detects endogenous levels of SULT1A1 at Human, Rat
Immunogen: Synthesized peptide derived from human SULT1A1
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin. Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil. Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Protein Name Sulfotransferase 1a1
St1a1
Aryl Sulfotransferase 1
Hast1/Hast2
Phenol Sulfotransferase 1
Phenol-Sulfating Phenol Sulfotransferase 1
P-Pst 1
St1a3
Thermostable Phenol Sulfotransferase
Ts-Pst
Database Links Reactome: R-HSA-156584
Reactome: R-HSA-9753281
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Sulfotransferase 1a1 antibody
Anti-St1a1 antibody
Anti-Aryl Sulfotransferase 1 antibody
Anti-Hast1/Hast2 antibody
Anti-Phenol Sulfotransferase 1 antibody
Anti-Phenol-Sulfating Phenol Sulfotransferase 1 antibody
Anti-P-Pst 1 antibody
Anti-St1a3 antibody
Anti-Thermostable Phenol Sulfotransferase antibody
Anti-Ts-Pst antibody
Anti-SULT1A1 antibody
Anti-STP antibody
Anti-STP1 antibody
Anti-OK antibody
Anti-SW-cl.88 antibody

Information sourced from Uniprot.org

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