Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-SULF1 (480-610) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
SULF1 |
Gene ID: |
23213 |
Uniprot ID: |
SULF1_HUMAN |
Immunogen Region: |
480-610 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 480-610 of human SULF1 (NP_001121676.1). |
Immunogen Sequence: |
SDLLTVRQSTRNLYARGFHD KDKECSCRESGYRASRSQRK SQRQFLRNQGTPKYKPRFVH TRQTRSLSVEFEGEIYDINL EEEEELQVLQPRNIAKRHDE GHKGPRDLQASSGGNRGRML ADSSNAVGPPT |
Tissue Specificity | Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines. |
Post Translational Modifications | Processing by furin produces a secreted form. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
Function | Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. |
Protein Name | Extracellular Sulfatase Sulf-1Hsulf-1ArylsulfataseN-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form |
Cellular Localisation | Endoplasmic ReticulumGolgi ApparatusGolgi StackCell SurfaceExtracellular Sulfatase Sulf-2 Secreted Form: Secreted |
Alternative Antibody Names | Anti-Extracellular Sulfatase Sulf-1 antibodyAnti-Hsulf-1 antibodyAnti-Arylsulfatase antibodyAnti-N-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form antibodyAnti-SULF1 antibodyAnti-KIAA1077 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance