Anti-SUDS3 antibody (96-146 aa) (STJ195428)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SDS3 at the amino acid range 96-146
General Information
| Short Description | Rabbit polyclonal anti-Sin3 histone deacetylase corepressor complex component SDS3 (96-146 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SUDS3 |
| Gene ID | 64426 |
| Uniprot ID | SDS3_HUMAN |
| Immunogen | Synthesized peptide derived from the human SDS3 at the amino acid range 96-146 |
| Immunogen Region | 96-146 aa |
| Specificity | This antibody detects endogenous levels of SDS3 at Human/Mouse |
Additional Info
| Post Translational Modifications | Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains. |
| Function | Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. |
| Protein Name | Sin3 Histone Deacetylase Corepressor Complex Component Sds345 Kda Sin3-Associated PolypeptideSuppressor Of Defective Silencing 3 Protein Homolog |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427413Reactome: R-HSA-5689880Reactome: R-HSA-9679191 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Sin3 Histone Deacetylase Corepressor Complex Component Sds3 antibodyAnti-45 Kda Sin3-Associated Polypeptide antibodyAnti-Suppressor Of Defective Silencing 3 Protein Homolog antibodyAnti-SUDS3 antibodyAnti-SAP45 antibodyAnti-SDS3 antibody |
Information sourced from Uniprot.org