| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sin3 histone deacetylase corepressor complex component SDS3 (96-146 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SUDS3 |
| Gene ID: |
64426 |
| Uniprot ID: |
SDS3_HUMAN |
| Immunogen Region: |
96-146 aa |
| Specificity: |
This antibody detects endogenous levels of SDS3 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human SDS3 at the amino acid range 96-146 |
| Post Translational Modifications | Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains. |
| Function | Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. |
| Protein Name | Sin3 Histone Deacetylase Corepressor Complex Component Sds345 Kda Sin3-Associated PolypeptideSuppressor Of Defective Silencing 3 Protein Homolog |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427413Reactome: R-HSA-5689880Reactome: R-HSA-9679191 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Sin3 Histone Deacetylase Corepressor Complex Component Sds3 antibodyAnti-45 Kda Sin3-Associated Polypeptide antibodyAnti-Suppressor Of Defective Silencing 3 Protein Homolog antibodyAnti-SUDS3 antibodyAnti-SAP45 antibodyAnti-SDS3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
