| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STXBP4 |
| Gene ID: | 252983 |
| Uniprot ID: | STXB4_HUMAN |
| Immunogen Region: | 344-553 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 344-553 of human STXBP4 (NP_848604.3). |
| Immunogen Sequence: | EETRALRSRIHLAEAAQRQA HGMEMDYEEVIRLLEAKITE LKAQLADYSDQNKESVQDLK KRIMVLDCQLRKSEMARKTF EASTEKLLHFVEAIQEVFSD NSTPLSNLSERRAVLASQTS LTPLGRNGRSIPATLALESK ELVKSVRALLDMDCLPYGWE EAYTADGIKYFINHVTQTTS WIHPVMSVLNLSRSEENEED CSRELPNQKS |
| Post Translational Modifications | Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A. |
| Function | Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. |
| Protein Name | Syntaxin-Binding Protein 4Syntaxin 4-Interacting ProteinStx4-Interacting ProteinSynip |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Syntaxin-Binding Protein 4 antibodyAnti-Syntaxin 4-Interacting Protein antibodyAnti-Stx4-Interacting Protein antibodyAnti-Synip antibodyAnti-STXBP4 antibody |
Information sourced from Uniprot.org