| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Syntaxin-4 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STX4 |
| Gene ID: | 6810 |
| Uniprot ID: | STX4_HUMAN |
| Specificity: | This antibody detects endogenous levels of Syntaxin 4 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human Syntaxin 4 |
| Function | Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing. |
| Protein Name | Syntaxin-4 Renal Carcinoma Antigen Ny-Ren-31 |
| Database Links | Reactome: R-HSA-114516 Reactome: R-HSA-1236974 Reactome: R-HSA-1445148 Reactome: R-HSA-199992 Reactome: R-HSA-449836 |
| Cellular Localisation | Cell Membrane Single-Pass Type Iv Membrane Protein Cell Projection Neuron Projection Stereocilium Localizes To Neurite Tips In Neuronal Cells |
| Alternative Antibody Names | Anti-Syntaxin-4 antibody Anti-Renal Carcinoma Antigen Ny-Ren-31 antibody Anti-STX4 antibody Anti-STX4A antibody |
Information sourced from Uniprot.org