Anti-STX17 antibody (30-80 aa) (STJ194556)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human STX17 at the amino acid range 30-80
General Information
| Short Description | Rabbit polyclonal anti-Syntaxin-17 (30-80 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STX17 |
| Gene ID | 55014 |
| Uniprot ID | STX17_HUMAN |
| Immunogen | Synthesized peptide derived from the human STX17 at the amino acid range 30-80 |
| Immunogen Region | 30-80 aa |
| Specificity | This antibody detects endogenous levels of STX17 at Human/Mouse/Rat |
Additional Info
| Function | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi. |
| Protein Name | Syntaxin-17 |
| Database Links | Reactome: R-HSA-204005 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinSmooth Endoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneCytoplasmic VesicleAutophagosome MembraneCopii-Coated Vesicle MembraneCytoplasmCytosolMitochondrion MembraneAutolysosome MembraneHas A Hairpin-Like Insertion Into MembranesLocalizes To The Completed Autophagosome Membrane Upon Cell StarvationColocalized With Rab39a And Rab39b In Autolysosomes In Autophagy-Induced Conditions |
| Alternative Antibody Names | Anti-Syntaxin-17 antibodyAnti-STX17 antibody |
Information sourced from Uniprot.org