| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Serine/threonine-protein kinase 38 (390-470 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STK38 |
| Gene ID: | 11329 |
| Uniprot ID: | STK38_HUMAN |
| Immunogen Region: | 390-470 aa |
| Specificity: | STK38 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 390-470 |
| Post Translational Modifications | ISGylated. Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. |
| Function | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation. |
| Protein Name | Serine/Threonine-Protein Kinase 38Ndr1 Protein KinaseNuclear Dbf2-Related Kinase 1 |
| Database Links | Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusCytoplasmChromosomeLocalizes To Dna Double-Strand Breaks In Response To Dna Damage |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 38 antibodyAnti-Ndr1 Protein Kinase antibodyAnti-Nuclear Dbf2-Related Kinase 1 antibodyAnti-STK38 antibodyAnti-NDR1 antibody |
Information sourced from Uniprot.org