| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Serine/threonine-protein kinase 10 (491-540 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STK10 |
| Gene ID: | 6793 |
| Uniprot ID: | STK10_HUMAN |
| Immunogen Region: | 491-540 aa |
| Specificity: | LOK Polyclonal Antibody detects endogenous levels of LOK protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human STK10 at the amino acid range 491-540 |
| Post Translational Modifications | Autophosphorylates following homodimerization, leading to activation of the protein. |
| Function | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro.however such data require additional evidences in vivo. |
| Protein Name | Serine/Threonine-Protein Kinase 10Lymphocyte-Oriented Kinase |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | Cell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 10 antibodyAnti-Lymphocyte-Oriented Kinase antibodyAnti-STK10 antibodyAnti-LOK antibody |
Information sourced from Uniprot.org
