Anti-Sterol carrier 2 antibody [R11-8P-8] (STJA0035590)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Sterol carrier protein 2
General Information
| Short Description | Rabbit monoclonal anti-Sterol carrier 2 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R11-8P-8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200IF 1:50-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SCP2 |
| Gene ID | 6342 |
| Uniprot ID | SCP2_HUMAN |
| Immunogen | A synthesized peptide derived from human Sterol carrier protein 2 |
Additional Info
| Tissue Specificity | Liver, fibroblasts, and placenta. |
| Post Translational Modifications | Isoform SCP2: preSCP2, a protein with a molecular mass of about 15 kDa, is processed into its mature form (SCP2) by proteolytic cleavage of a 20 residue leader sequence after translocation into peroxisomes. |
| Function | Isoform SCPx: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs. Isoform SCP2: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs. |
| Protein Name | Sterol Carrier Protein 2Scp-2Acetyl-Coa C-MyristoyltransferaseNon-Specific Lipid-Transfer ProteinNsl-TpPropanoyl-Coa C-AcyltransferaseScp-2/3-Oxoacyl-Coa ThiolaseScp-2/ThiolaseScp-ChiScpxSterol Carrier Protein XScp-X |
| Database Links | Reactome: R-HSA-193368 P22307-1Reactome: R-HSA-2046106Reactome: R-HSA-389887 P22307-1Reactome: R-HSA-9033241Reactome: R-HSA-9033500 |
| Cellular Localisation | Isoform Scp2: PeroxisomeCytoplasmMitochondrionEndoplasmic ReticulumIsoform Scpx: Peroxisome |
| Alternative Antibody Names | Anti-Sterol Carrier Protein 2 antibodyAnti-Scp-2 antibodyAnti-Acetyl-Coa C-Myristoyltransferase antibodyAnti-Non-Specific Lipid-Transfer Protein antibodyAnti-Nsl-Tp antibodyAnti-Propanoyl-Coa C-Acyltransferase antibodyAnti-Scp-2/3-Oxoacyl-Coa Thiolase antibodyAnti-Scp-2/Thiolase antibodyAnti-Scp-Chi antibodyAnti-Scpx antibodyAnti-Sterol Carrier Protein X antibodyAnti-Scp-X antibodyAnti-SCP2 antibody |
Information sourced from Uniprot.org