Anti-STAT 1 antibody [SM1] (STJ16100213)

Anti-STAT 1 antibody [SM1] (STJ16100213)

⇓ Datasheet ⇓ SDS
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenSTAT1 peptide sequence 721-733 (DNLLPMSPEEFDE).
STJ16100213-01
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General Information

Short DescriptionMouse monoclonal anti-STAT 1 for use in IP, WB and IHC-P in Mouse and Human samples. Datasheet included with dilution recommendations, and related reagents.
ApplicationsIP/WB/IHC-P
HostMouse
ReactivityMouse/Human
NoteSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

ClonalityMonoclonal
Clone IDSM1
IsotypeIgG2b
ConjugationUnconjugated
Concentration1 mg/mL
FormulationPhosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage InstructionStore at 2-8°C for up to 1-year, upon receipt.

Target Information

ImmunogenSTAT1 peptide sequence 721-733 (DNLLPMSPEEFDE).

Additional Info

Background STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.

Information sourced from Uniprot.org

Citations

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