Anti-STARD3 antibody (STJ193076)

SKU:
STJ193076

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-StAR-related lipid transfer protein 3 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: STARD3
Gene ID: 10948
Uniprot ID: STAR3_HUMAN
Specificity: STAR3 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Phosphorylation at Ser-209 is necessary and sufficient for the direct interaction of the phosphorylated FFAT motif with the MSP domain of MOSPD2, VAPA and VAPB and allows the tethering of two membranes that participates in the formation of ER-endosome contacts. Phosphorylation of the FFAT motif leads to conformation changes. Additional phosphorylations around the core FFAT motif (QFYSPPE) are not essential but strengthen the interaction with MOSPD2, VAPA and VAPB. Phosphorylation at Ser-209 of FFAT motif drives membrane tethering between the endoplasmic reticulum and late endosomes via interaction with VAPA and VAPB that in turn allows the efficient transport of sterol mediated by the START domain.
Function Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. The sterol transport mechanism is triggered by phosphorylation of FFAT motif that leads to membrane tethering between the endoplasmic reticulum and late endosomes via interaction with VAPA and VAPB. Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes. May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane. However, such results need additional experimental evidences.probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes. Does not activate transcriptional cholesterol sensing. Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina.
Protein Name Star-Related Lipid Transfer Protein 3
Metastatic Lymph Node Gene 64 Protein
Mln 64
Protein Cab1
Start Domain-Containing Protein 3
Stard3
Database Links Reactome: R-HSA-196108
Cellular Localisation Late Endosome Membrane
Multi-Pass Membrane Protein
Localizes To Contact Sites Between The Endoplasmic Reticulum And Late Endosomes: Associates With The Endoplasmic Reticulum Membrane Via Interaction With Vapa
Vapb Or Mospd2
Alternative Antibody Names Anti-Star-Related Lipid Transfer Protein 3 antibody
Anti-Metastatic Lymph Node Gene 64 Protein antibody
Anti-Mln 64 antibody
Anti-Protein Cab1 antibody
Anti-Start Domain-Containing Protein 3 antibody
Anti-Stard3 antibody
Anti-STARD3 antibody
Anti-CAB1 antibody
Anti-MLN64 antibody

Information sourced from Uniprot.org

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