| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STAMBPL1 |
| Gene ID: | 57559 |
| Uniprot ID: | STALP_HUMAN |
| Immunogen Region: | 120-250 |
| Immunogen Sequence: | ELKNDLLKKYNVEYQEYLQS KNKYKAEILKKLEHQRLIEA ERKRIAQMRQQQLESEQFLF FEDQLKKQELARGQMRSQQT SGLSEQIDGSALSCFSTHQN NSLLNVFADQPNKSDATNYA SHSPPVNRALT |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-250 of human STAMBPL1 (NP_065850.1). |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains. |
| Protein Name | Amsh-Like ProteaseAmsh-LpStam-Binding Protein-Like 1 |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Amsh-Like Protease antibodyAnti-Amsh-Lp antibodyAnti-Stam-Binding Protein-Like 1 antibodyAnti-STAMBPL1 antibodyAnti-AMSHLP antibodyAnti-KIAA1373 antibody |
Information sourced from Uniprot.org
