| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11. |
| Function | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. |
| Protein Name | Stam-Binding ProteinAssociated Molecule With The Sh3 Domain Of StamEndosome-Associated Ubiquitin Isopeptidase |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | NucleusMembranePeripheral Membrane ProteinCytoplasmEarly Endosome |
| Alternative Antibody Names | Anti-Stam-Binding Protein antibodyAnti-Associated Molecule With The Sh3 Domain Of Stam antibodyAnti-Endosome-Associated Ubiquitin Isopeptidase antibodyAnti-STAMBP antibodyAnti-AMSH antibody |
Information sourced from Uniprot.org
