Anti-STAMBP antibody (100-270) (STJ29145)

Name: Anti-STAMBP antibody (100-270) (STJ29145)
SKU: STJ29145
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ29145

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Short Description	Rabbit polyclonal STAMBP (100-270) antibody for use in WB, IHC-P, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/IP/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:100 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	STAMBP
Gene ID	10617
Uniprot ID	STABP_HUMAN
Immunogen Region	100-270
Immunogen Sequence	FPKAEELKAELLKRYTKEYT EYNEEKKKEAEELARNMAIQ QELEKEKQRVAQQKQQQLEQ EQFHAFEEMIRNQELEKERL KIVQEFGKVDPGLGGPLVPD LEKPSLDVFPTLTVSSIQPS DCHTTVRPAKPPVVDRSLKP GALSNSESIPTIDGLRHVVV PGRLCPQFLQL
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 100-270 of human STAMBP (NP_998787.1).

Tissue Specificity	Ubiquitously expressed.
Post Translational Modifications	Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11.
Function	Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Protein Name	Stam-Binding Protein Associated Molecule With The Sh3 Domain Of Stam Endosome-Associated Ubiquitin Isopeptidase
Database Links	Reactome: R-HSA-5689901
Cellular Localisation	Nucleus Membrane Peripheral Membrane Protein Cytoplasm Early Endosome
Alternative Antibody Names	Anti-Stam-Binding Protein antibody Anti-Associated Molecule With The Sh3 Domain Of Stam antibody Anti-Endosome-Associated Ubiquitin Isopeptidase antibody Anti-STAMBP antibody Anti-AMSH antibody

Information sourced from Uniprot.org