| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-STAG3 (Internal) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
STAG3 |
| Gene ID: |
10734 |
| Uniprot ID: |
STAG3_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_036579.2 |
| Immunogen Sequence: |
KPNREDVSSSQEE |
| Post Translational Modifications | Phosphorylated. |
| Function | Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. |
| Protein Name | Cohesin Subunit Sa-3Scc3 Homolog 3Stromal Antigen 3Stromalin-3 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | NucleusChromosomeCentromereAssociates With ChromatinIn Prophase I Stage Of MeiosisIt Is Found Along The Axial Elements Of Synaptonemal ComplexesIn Late-Pachytene-DiploteneThe Bulk Of Protein Dissociates From The Chromosome Arms Probably Because Of Phosphorylation By Plk1Except At CentromeresWhere Cohesin Complexes RemainIt However Remains Chromatin Associated At The Centromeres Up To Metaphase IDuring Anaphase IIt Probably Dissociates From CentromeresAllowing Chromosomes Segregation |
| Alternative Antibody Names | Anti-Cohesin Subunit Sa-3 antibodyAnti-Scc3 Homolog 3 antibodyAnti-Stromal Antigen 3 antibodyAnti-Stromalin-3 antibodyAnti-STAG3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
