Anti-STAG3 antibody (1161-1210 aa) (STJ95799)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human STAG3 at the amino acid range 1161-1210
General Information
| Short Description | Rabbit polyclonal anti-Cohesin subunit SA-3 (1161-1210 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STAG3 |
| Gene ID | 10734 |
| Uniprot ID | STAG3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human STAG3 at the amino acid range 1161-1210 |
| Immunogen Region | 1161-1210 aa |
| Specificity | STAG3 Polyclonal Antibody detects endogenous levels of STAG3 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated. |
| Function | Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. |
| Protein Name | Cohesin Subunit Sa-3Scc3 Homolog 3Stromal Antigen 3Stromalin-3 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | NucleusChromosomeCentromereAssociates With ChromatinIn Prophase I Stage Of MeiosisIt Is Found Along The Axial Elements Of Synaptonemal ComplexesIn Late-Pachytene-DiploteneThe Bulk Of Protein Dissociates From The Chromosome Arms Probably Because Of Phosphorylation By Plk1Except At CentromeresWhere Cohesin Complexes RemainIt However Remains Chromatin Associated At The Centromeres Up To Metaphase IDuring Anaphase IIt Probably Dissociates From CentromeresAllowing Chromosomes Segregation |
| Alternative Antibody Names | Anti-Cohesin Subunit Sa-3 antibodyAnti-Scc3 Homolog 3 antibodyAnti-Stromal Antigen 3 antibodyAnti-Stromalin-3 antibodyAnti-STAG3 antibody |
Information sourced from Uniprot.org