• STJ71187 (0. 01µg/ml) staining of HeLa cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-STAG2 antibody (Internal) (STJ71187)

SKU:
STJ71187-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-STAG2 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.01µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: STAG2
Gene ID: 10735
Uniprot ID: STAG2_HUMAN
Immunogen Region: Internal
Accession Number: NP_001036214.1; NP_001036215.1 ; NP_001036216.1 ; NP_006594.3
Specificity: This antibody is expected to recognise isoform a (NP_001036214.1 and NP_001036215.1) and isoform b (NP_001036216.1 and NP_006594.3).
Immunogen Sequence: REPKRLRPEDS
Function Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Protein Name Cohesin Subunit Sa-2
Scc3 Homolog 2
Stromal Antigen 2
Database Links Reactome: R-HSA-1221632
Reactome: R-HSA-2467813
Reactome: R-HSA-2468052
Reactome: R-HSA-2470946
Reactome: R-HSA-2500257
Reactome: R-HSA-3108214
Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Chromosome
Centromere
Associates With Chromatin
Before Prophase It Is Scattered Along Chromosome Arms
During Prophase
Most Of Cohesin Complexes Dissociate From Chromatin Probably Because Of Phosphorylation By Plk1
Except At Centromeres
Where Cohesin Complexes Remain
At Anaphase
The Rad21 Subunit Of Cohesin Is Cleaved
Leading To The Dissociation Of The Complex From Chromosomes
Allowing Chromosome Separation
In Germ Cells
Cohesin Complex Dissociates From Chromatin At Prophase I
And May Be Replaced By A Meiosis-Specific Cohesin Complex
Alternative Antibody Names Anti-Cohesin Subunit Sa-2 antibody
Anti-Scc3 Homolog 2 antibody
Anti-Stromal Antigen 2 antibody
Anti-STAG2 antibody
Anti-SA2 antibody

Information sourced from Uniprot.org

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