| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sia-alpha-2, 3-Gal-beta-1, 4-GlcNAc-R:alpha 2, 8-sialyltransferase is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ST8SIA3 |
| Gene ID: |
51046 |
| Uniprot ID: |
SIA8C_HUMAN |
| Specificity: |
This antibody detects endogenous levels of ST8SIA3 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human ST8SIA3 |
| Post Translational Modifications | Autopolysialylated. |
| Function | Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an acceptor, such as N-linked oligosaccharides of glycoproteins and glycolipids through alpha-2,8-linkages. Forms oligosialic and polysialic acid on various sialylated N-acetyllactosamine oligosaccharides of glycoproteins, including FETUB N-glycans, a2-HS-glycoprotein (AHSG) and alpha 2,3-sialylated glycosphingolipids, such as alpha 2,3-sialylparagloboside and ganglioside GM3 and to a lesser extent NCAM1 N-glycans. However, it is much more specific to N-linked oligosaccharides of glycoproteins than glycosphingolipids. 2,3-sialylparagloboside serves as the best acceptor substrate among the glycolipids. alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc and monosialyl and disialyl N-acetyllactosamines are the best acceptor substrates among glycoproteins. May plays critical role in the striatum by mediating the formation of disialylated and trisialylated terminal glycotopes on N- and O-glycans of specific striatal proteins, regulating their distribution in lipid rafts, affecting their interaction with other binding partners, and subsequently modulating striatal functions. |
| Protein Name | Alpha-N-Acetylneuraminate Alpha-2 -8-Sialyltransferase St8sia3Alpha-2 -8-Sialyltransferase 8cAlpha-2 -8-Sialyltransferase IiiGanglioside Gd3 Synthase St8sia3St8 Alpha-N-Acetyl-Neuraminide Alpha-2 -8-Sialyltransferase 3Sia-A2 -3-Gal-B1 -4-Glc-Nac-R -A2 -8-SialyltransferaseHst8sia IiiSialyltransferase 8cSiat8-CSialyltransferase St8sia IiiSt8siaiii |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-975577 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Alpha-N-Acetylneuraminate Alpha-2 -8-Sialyltransferase St8sia3 antibodyAnti-Alpha-2 -8-Sialyltransferase 8c antibodyAnti-Alpha-2 -8-Sialyltransferase Iii antibodyAnti-Ganglioside Gd3 Synthase St8sia3 antibodyAnti-St8 Alpha-N-Acetyl-Neuraminide Alpha-2 -8-Sialyltransferase 3 antibodyAnti-Sia-A2 -3-Gal-B1 -4-Glc-Nac-R -A2 -8-Sialyltransferase antibodyAnti-Hst8sia Iii antibodyAnti-Sialyltransferase 8c antibodyAnti-Siat8-C antibodyAnti-Sialyltransferase St8sia Iii antibodyAnti-St8siaiii antibodyAnti-ST8SIA3 antibodyAnti-SIAT8C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
