| Function | Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside). |
| Protein Name | Alpha-N-Acetylgalactosaminide Alpha-2 -6-Sialyltransferase 6Galnac Alpha-2 -6-Sialyltransferase ViSt6galnac ViSt6galnacviHst6galnac ViSialyltransferase 7fSiat7-F |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-9037629Reactome: R-HSA-9840309 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Alpha-N-Acetylgalactosaminide Alpha-2 -6-Sialyltransferase 6 antibodyAnti-Galnac Alpha-2 -6-Sialyltransferase Vi antibodyAnti-St6galnac Vi antibodyAnti-St6galnacvi antibodyAnti-Hst6galnac Vi antibodyAnti-Sialyltransferase 7f antibodyAnti-Siat7-F antibodyAnti-ST6GALNAC6 antibodyAnti-SIAT7F antibodyAnti-UNQ708 antibodyAnti-PRO1359 antibody |
Information sourced from Uniprot.org
