| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ST3GAL2 (30-210) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ST3GAL2 |
| Gene ID: |
6483 |
| Uniprot ID: |
SIA4B_HUMAN |
| Immunogen Region: |
30-210 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-210 of human ST3GAL2 (NP_008858.1). |
| Immunogen Sequence: |
SMATLPYLDSGALDGTHRVK LVPGYAGLQRLSKERLSGKS CACRRCMGDAGASDWFDSHF DGNISPVWTRENMDLPPDVQ RWWMMLQPQFKSHNTNEVLE KLFQIVPGENPYRFRDPHQC RRCAVVGNSGNLRGSGYGQD VDGHNFIMRMNQAPTVGFEQ DVGSRTTHHFMYPESAKNLP A |
| Tissue Specificity | Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney. |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. N-glycosylated.necessary for proper exit from endoplasmic reticulum and trafficking to the Golgi apparatus. |
| Function | A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid.Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration. Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury. Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4. Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser. |
| Protein Name | Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 2Alpha 2 -3-St 2Beta-Galactoside Alpha-2 -3-Sialyltransferase 2Gal-Nac6sGal-Beta-1 -3-Galnac-Alpha-2 -3-SialyltransferaseMonosialoganglioside SialyltransferaseSt3gal IiSt3galiiSt3gala.2Sialyltransferase 4bSiat4-B |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-4085001Reactome: R-HSA-9683673Reactome: R-HSA-9694548Reactome: R-HSA-9694719Reactome: R-HSA-977068 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinSecretedMembrane-Bound Form Distributed Along The Golgi CisternaeMainly In Proximal CompartmentsSecreted Into The Body Fluid |
| Alternative Antibody Names | Anti-Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 2 antibodyAnti-Alpha 2 -3-St 2 antibodyAnti-Beta-Galactoside Alpha-2 -3-Sialyltransferase 2 antibodyAnti-Gal-Nac6s antibodyAnti-Gal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase antibodyAnti-Monosialoganglioside Sialyltransferase antibodyAnti-St3gal Ii antibodyAnti-St3galii antibodyAnti-St3gala.2 antibodyAnti-Sialyltransferase 4b antibodyAnti-Siat4-B antibodyAnti-ST3GAL2 antibodyAnti-SIAT4B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
