Anti-SSBP1 antibody (99-148 aa) (STJ95791)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human MtSSB at the amino acid range 99-148
General Information
| Short Description | Rabbit polyclonal anti-Single-stranded DNA-binding protein, mitochondrial (99-148 aa) for use in WB, IHC, IF and ELISA in Human, Mouse, Rat and Cow samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SSBP1 |
| Gene ID | 6742 |
| Uniprot ID | SSBP_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human MtSSB at the amino acid range 99-148 |
| Immunogen Region | 99-148 aa |
| Specificity | SSBP1 Polyclonal Antibody detects endogenous levels of SSBP1 protein. |
Additional Info
| Function | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair. |
| Protein Name | Single-Stranded Dna-Binding Protein - MitochondrialMt-SsbMtssbPwp1-Interacting Protein 17 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-9837999Reactome: R-HSA-9913635 |
| Cellular Localisation | MitochondrionMitochondrion MatrixMitochondrion Nucleoid |
| Alternative Antibody Names | Anti-Single-Stranded Dna-Binding Protein - Mitochondrial antibodyAnti-Mt-Ssb antibodyAnti-Mtssb antibodyAnti-Pwp1-Interacting Protein 17 antibodyAnti-SSBP1 antibodyAnti-SSBP antibody |
Information sourced from Uniprot.org