| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Serine/arginine-rich splicing factor 10 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SRSF10 |
| Gene ID: |
10772 |
| Uniprot ID: |
SRS10_HUMAN |
| Specificity: |
This antibody detects endogenous levels of FUSIP1 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human FUSIP1 |
| Post Translational Modifications | Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. |
| Function | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 1040 Kda Sr-Repressor ProteinSrrp40Fus-Interacting Serine-Arginine-Rich Protein 1Splicing Factor Srp38Splicing Factor - Arginine/Serine-Rich 13aTls-Associated Protein With Ser-Arg RepeatsTasrTls-Associated Protein With Sr RepeatsTls-Associated Serine-Arginine ProteinTls-Associated Sr Protein |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203 |
| Cellular Localisation | Nucleus SpeckleCytoplasm |
| Alternative Antibody Names | Anti-Serine/Arginine-Rich Splicing Factor 10 antibodyAnti-40 Kda Sr-Repressor Protein antibodyAnti-Srrp40 antibodyAnti-Fus-Interacting Serine-Arginine-Rich Protein 1 antibodyAnti-Splicing Factor Srp38 antibodyAnti-Splicing Factor - Arginine/Serine-Rich 13a antibodyAnti-Tls-Associated Protein With Ser-Arg Repeats antibodyAnti-Tasr antibodyAnti-Tls-Associated Protein With Sr Repeats antibodyAnti-Tls-Associated Serine-Arginine Protein antibodyAnti-Tls-Associated Sr Protein antibodyAnti-SRSF10 antibodyAnti-FUSIP1 antibodyAnti-FUSIP2 antibodyAnti-SFRS13A antibodyAnti-TASR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
